Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm

<jats:p>Recombination is critical to meiosis and evolution, yet many aspects of the physical exchange of DNA via crossovers remain poorly understood. We report an approach for single-cell whole-genome DNA sequencing by which we sequenced 217 individual hybrid mouse sperm, providing a kilobase-...

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Hlavní autoři: Hinch, A, Zhang, G, Becker, P, Moralli, D, Hinch, R, Davies, B, Bowden, R, Donnelly, P
Médium: Journal article
Jazyk:English
Vydáno: American Association for the Advancement of Science 2019