Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy.
We have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin there is occupation of erythrocytic card...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1981
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| _version_ | 1797091127227056128 |
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| author | Aronson, J Ford, A Grahame-Smith, D |
| author_facet | Aronson, J Ford, A Grahame-Smith, D |
| author_sort | Aronson, J |
| collection | OXFORD |
| description | We have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin there is occupation of erythrocytic cardiac glycoside receptors by digoxin with resultant inhibition of active cation transport. These effects correlate well with the patients' clinical responses to treatment. During long-term treatment, however, these effects are not seen, suggesting that there is pharmacological tolerance to the effects of digoxin. The clinical implications of these results are discussed. |
| first_indexed | 2024-03-07T03:28:38Z |
| format | Journal article |
| id | oxford-uuid:b9ecad41-778b-4da6-8917-0f269365c1dd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:28:38Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:b9ecad41-778b-4da6-8917-0f269365c1dd2022-03-27T05:06:21ZTechniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b9ecad41-778b-4da6-8917-0f269365c1ddEnglishSymplectic Elements at Oxford1981Aronson, JFord, AGrahame-Smith, DWe have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin there is occupation of erythrocytic cardiac glycoside receptors by digoxin with resultant inhibition of active cation transport. These effects correlate well with the patients' clinical responses to treatment. During long-term treatment, however, these effects are not seen, suggesting that there is pharmacological tolerance to the effects of digoxin. The clinical implications of these results are discussed. |
| spellingShingle | Aronson, J Ford, A Grahame-Smith, D Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy. |
| title | Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy. |
| title_full | Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy. |
| title_fullStr | Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy. |
| title_full_unstemmed | Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy. |
| title_short | Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy. |
| title_sort | techniques for studying the pharmacodynamic effects of cardiac glycosides on patients own erythrocytes during glycoside therapy |
| work_keys_str_mv | AT aronsonj techniquesforstudyingthepharmacodynamiceffectsofcardiacglycosidesonpatientsownerythrocytesduringglycosidetherapy AT forda techniquesforstudyingthepharmacodynamiceffectsofcardiacglycosidesonpatientsownerythrocytesduringglycosidetherapy AT grahamesmithd techniquesforstudyingthepharmacodynamiceffectsofcardiacglycosidesonpatientsownerythrocytesduringglycosidetherapy |