Multivariable regression models improve accuracy and sensitive grading of antibiotic resistance mutations in Mycobacterium tuberculosis

Rapid genotype-based drug susceptibility testing for the Mycobacterium tuberculosis complex (MTBC) relies on a comprehensive knowledgebase of the genetic determinants of resistance. Here we present a catalogue of resistance-associated mutations using a regression-based approach and benchmark it agai...

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Detalhes bibliográficos
Main Authors: Kulkarni, SG, Laurent, S, Miotto, P, Walker, TM, Chindelevitch, L, Nathanson, C, Ismail, N, Rodwell, TC, Farhat, MR
Formato: Journal article
Idioma:English
Publicado em: Nature Research 2025