A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.

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AIMS/HYPOTHESIS: Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4α (HNF-4A), account for ~5% of cases of MODY and more frequent variants in this gene may be involved in multifactorial forms of diabetes. Two low-frequency, non-synonymous variants in HNF...

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Main Authors: Jafar-Mohammadi, B, Groves, C, Gjesing, A, Herrera, B, Winckler, W, Stringham, H, Morris, A, Lauritzen, T, Doney, A, Weedon, M, Swift, A, Kuusisto, J, Laakso, M, Altshuler, D, Hattersley, A, Collins, F, Boehnke, M, Hansen, T, Pedersen, O, Palmer, C, Frayling, T, Gloyn, A, McCarthy, M
格式: Journal article
语言:English
出版: 2011

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