Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.

Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.

An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to effl...

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Dettagli Bibliografici
Autori principali:	Ch'ng, J, Lee, Y, Gun, S, Chia, W, Chang, Z, Wong, L, Batty, K, Russell, B, Nosten, F, Renia, L, Tan, K
Natura:	Journal article
Lingua:	English
Pubblicazione:	Nature Publishing Group 2014
Soggetti:	Malaria Pharmacology

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