Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis
Despite nature’s prevalent use of metals as prosthetics to adapt or enhance the behaviour of proteins, our ability to programme such architectural organization remains underdeveloped. Multi-metal clusters buried in proteins underpin the most remarkable chemical transformations in nature, but we are...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society
2016
|
| _version_ | 1797091184510763008 |
|---|---|
| author | Fehl, C Davis, B |
| author_facet | Fehl, C Davis, B |
| author_sort | Fehl, C |
| collection | OXFORD |
| description | Despite nature’s prevalent use of metals as prosthetics to adapt or enhance the behaviour of proteins, our ability to programme such architectural organization remains underdeveloped. Multi-metal clusters buried in proteins underpin the most remarkable chemical transformations in nature, but we are not yet in a position to fully mimic or exploit such systems. With the advent of copious, relevant structural information, judicious mechanistic studies and the use of accessible computational methods in protein design coupled with new synthetic methods for building biomacromolecules, we can envisage a ‘new dawn’ that will allow us to build de novo metalloenzymes that move beyond mono-metal centres. In particular, we highlight the need for systems that approach the multi-centred clusters that have evolved to couple electron shuttling with catalysis. Such hybrids may be viewed as exciting mid-points between homogeneous and heterogeneous catalysts which also exploit the primary benefits of biocatalysis. |
| first_indexed | 2024-03-07T03:29:24Z |
| format | Journal article |
| id | oxford-uuid:ba2bad52-b22e-4fe6-b918-3261480f077c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:29:24Z |
| publishDate | 2016 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:ba2bad52-b22e-4fe6-b918-3261480f077c2022-03-27T05:08:04ZProteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ba2bad52-b22e-4fe6-b918-3261480f077cEnglishSymplectic Elements at OxfordRoyal Society2016Fehl, CDavis, BDespite nature’s prevalent use of metals as prosthetics to adapt or enhance the behaviour of proteins, our ability to programme such architectural organization remains underdeveloped. Multi-metal clusters buried in proteins underpin the most remarkable chemical transformations in nature, but we are not yet in a position to fully mimic or exploit such systems. With the advent of copious, relevant structural information, judicious mechanistic studies and the use of accessible computational methods in protein design coupled with new synthetic methods for building biomacromolecules, we can envisage a ‘new dawn’ that will allow us to build de novo metalloenzymes that move beyond mono-metal centres. In particular, we highlight the need for systems that approach the multi-centred clusters that have evolved to couple electron shuttling with catalysis. Such hybrids may be viewed as exciting mid-points between homogeneous and heterogeneous catalysts which also exploit the primary benefits of biocatalysis. |
| spellingShingle | Fehl, C Davis, B Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis |
| title | Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis |
| title_full | Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis |
| title_fullStr | Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis |
| title_full_unstemmed | Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis |
| title_short | Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis |
| title_sort | proteins as templates for complex synthetic metalloclusters towards biologically programmed heterogeneous catalysis |
| work_keys_str_mv | AT fehlc proteinsastemplatesforcomplexsyntheticmetalloclusterstowardsbiologicallyprogrammedheterogeneouscatalysis AT davisb proteinsastemplatesforcomplexsyntheticmetalloclusterstowardsbiologicallyprogrammedheterogeneouscatalysis |