Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies.

Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies.

A bioanalytical method for the analysis of artesunate (ARS) and its metabolite dihydroartemisinin (DHA) in human plasma using protein precipitation and liquid chromatography coupled to positive tandem mass spectroscopy was developed. The method was validated according to published US FDA-guidelines...

Bibliografski detalji
Glavni autori:	Lindegardh, N, Hanpithakpong, W, Kamanikom, B, Singhasivanon, P, Socheat, D, Yi, P, Dondorp, A, Mcgready, R, Nosten, F, White, N, Day, N
Format:	Journal article
Jezik:	English
Izdano:	2008

Slični predmeti

Quantification of dihydroartemisinin, artesunate and artemisinin in human blood: overcoming the technical challenge of protecting the peroxide bridge.
od: Lindegardh, N, i dr.
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A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma.
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A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma.
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Intrahost modeling of artemisinin resistance in Plasmodium falciparum
od: Saralamba, S, i dr.
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Intrahost modeling of artemisinin resistance in Plasmodium falciparum.
od: Saralamba, S, i dr.
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Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry.
od: Lindegardh, N, i dr.
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Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of oseltamivir and its metabolite oseltamivir carboxylate in plasma, saliva and urine.
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Artemisinin Resistance in Plasmodium falciparum Malaria (vol 361, pg 455, 2009)
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Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria.
od: Das, D, i dr.
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od: Dondorp, A, i dr.
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Intrarectal artemisinin derivatives.
od: Nosten, F, i dr.
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od: Phyo, A, i dr.
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od: Chotivanich, K, i dr.
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od: Lindegardh, N, i dr.
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od: Tarning, J, i dr.
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od: Nosten, F, i dr.
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od: Mcgready, R, i dr.
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Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples.
od: Lindegårdh, N, i dr.
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Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum.
od: Teja-Isavadharm, P, i dr.
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Population pharmacokinetic and pharmacodynamic modeling of artemisinin resistance in Southeast Asia
od: Lohy Das, J, i dr.
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A major genome region underlying artemisinin resistance in malaria.
od: Cheeseman, I, i dr.
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od: Cheeseman, I, i dr.
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Studies of the neurotoxicity of oral artemisinin derivatives in mice.
od: Nontprasert, A, i dr.
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Pitfalls in estimating piperaquine elimination.
od: Tarning, J, i dr.
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Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance.
od: Maude, R, i dr.
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Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
od: Lindegardh, N, i dr.
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od: Ashley, E, i dr.
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Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.
od: Mok, S, i dr.
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Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.
od: Tarning, J, i dr.
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Neuropathologic toxicity of artemisinin derivatives in a mouse model.
od: Nontprasert, A, i dr.
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od: Nontprasert, A, i dr.
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od: Ashley, E, i dr.
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