Glucose turnover in pregnant women with acute malaria.
1. Hypoglycaemia is a serious complication of falciparum malaria, especially in pregnant patients. To investigate malaria-associated changes in glucose metabolism in pregnancy, steady-state [6,6-2H2] glucose turnover and clearance were measured in 10 women (eight with uncomplicated falciparum malari...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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1994
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| _version_ | 1797091227465678848 |
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| author | Davis, T Suputtamongkol, Y Spencer, J Wilson, S Mekhton, S Croft, K White, N |
| author_facet | Davis, T Suputtamongkol, Y Spencer, J Wilson, S Mekhton, S Croft, K White, N |
| author_sort | Davis, T |
| collection | OXFORD |
| description | 1. Hypoglycaemia is a serious complication of falciparum malaria, especially in pregnant patients. To investigate malaria-associated changes in glucose metabolism in pregnancy, steady-state [6,6-2H2] glucose turnover and clearance were measured in 10 women (eight with uncomplicated falciparum malaria and two with vivax malaria at 16-30 weeks gestation) before treatment, after intravenous quinine infusion (patients with falciparum malaria) and in convalescence. 2. Admission basal plasma glucose concentrations were higher than those in convalescence [median (range); 4.8 (3.6-7.0) versus 4.0 (3.6-4.6) mmol/l, P = 0.02], and there was a significant fall during initial quinine treatment in patients with falciparum malaria [5.0 (4.3-7.6) to 3.6 (3.2-5.4) mmol/l, P < 0.01]. Basal plasma insulin levels were comparable at presentation and follow-up (P = 0.35) and rose an average of only 2m-units/l during quinine infusion (P < 0.05). Pretreatment glucose turnover rates [3.37 (2.57-4.16) mg min-1 kg-1] were comparable with those found in a previously reported study of non-pregnant severely ill patients [3.22 (2.12-4.82) mg min-1 kg-1, n = 11] and correlated significantly with the admission parasitaemia (P < 0.025). In the eight patients with falciparum malaria, there was a significant fall in turnover during intravenous quinine infusion [3.42 (2.58-4.16) to 2.66 [1.94-3.94) mg min-1 kg-1] whereas clearance did not change significantly.(ABSTRACT TRUNCATED AT 250 WORDS) |
| first_indexed | 2024-03-07T03:29:58Z |
| format | Journal article |
| id | oxford-uuid:ba6215b6-2bc1-4bda-b1bb-eff3edefd2ec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:29:58Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:ba6215b6-2bc1-4bda-b1bb-eff3edefd2ec2022-03-27T05:09:27ZGlucose turnover in pregnant women with acute malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ba6215b6-2bc1-4bda-b1bb-eff3edefd2ecEnglishSymplectic Elements at Oxford1994Davis, TSuputtamongkol, YSpencer, JWilson, SMekhton, SCroft, KWhite, N1. Hypoglycaemia is a serious complication of falciparum malaria, especially in pregnant patients. To investigate malaria-associated changes in glucose metabolism in pregnancy, steady-state [6,6-2H2] glucose turnover and clearance were measured in 10 women (eight with uncomplicated falciparum malaria and two with vivax malaria at 16-30 weeks gestation) before treatment, after intravenous quinine infusion (patients with falciparum malaria) and in convalescence. 2. Admission basal plasma glucose concentrations were higher than those in convalescence [median (range); 4.8 (3.6-7.0) versus 4.0 (3.6-4.6) mmol/l, P = 0.02], and there was a significant fall during initial quinine treatment in patients with falciparum malaria [5.0 (4.3-7.6) to 3.6 (3.2-5.4) mmol/l, P < 0.01]. Basal plasma insulin levels were comparable at presentation and follow-up (P = 0.35) and rose an average of only 2m-units/l during quinine infusion (P < 0.05). Pretreatment glucose turnover rates [3.37 (2.57-4.16) mg min-1 kg-1] were comparable with those found in a previously reported study of non-pregnant severely ill patients [3.22 (2.12-4.82) mg min-1 kg-1, n = 11] and correlated significantly with the admission parasitaemia (P < 0.025). In the eight patients with falciparum malaria, there was a significant fall in turnover during intravenous quinine infusion [3.42 (2.58-4.16) to 2.66 [1.94-3.94) mg min-1 kg-1] whereas clearance did not change significantly.(ABSTRACT TRUNCATED AT 250 WORDS) |
| spellingShingle | Davis, T Suputtamongkol, Y Spencer, J Wilson, S Mekhton, S Croft, K White, N Glucose turnover in pregnant women with acute malaria. |
| title | Glucose turnover in pregnant women with acute malaria. |
| title_full | Glucose turnover in pregnant women with acute malaria. |
| title_fullStr | Glucose turnover in pregnant women with acute malaria. |
| title_full_unstemmed | Glucose turnover in pregnant women with acute malaria. |
| title_short | Glucose turnover in pregnant women with acute malaria. |
| title_sort | glucose turnover in pregnant women with acute malaria |
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