A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly
Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at a single focus that defines the daughter cent...
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
Public Library of Science
2023
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| _version_ | 1826311555264806912 |
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| author | Wilmott, Z Goriely, A Raff, J |
| author_facet | Wilmott, Z Goriely, A Raff, J |
| author_sort | Wilmott, Z |
| collection | OXFORD |
| description | Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at a single focus that defines the daughter centriole assembly site. How PLK4 breaks symmetry is unclear. Here, we propose that phosphorylated and unphosphorylated species of PLK4 form the 2 components of a classical Turing reaction–diffusion system. These 2 components bind to/unbind from the surface of the mother centriole at different rates, allowing a slow-diffusing activator species of PLK4 to accumulate at a single site on the mother, while a fast-diffusing inhibitor species of PLK4 suppresses activator accumulation around the rest of the centriole. This “short-range activation/long-range inhibition,” inherent to Turing systems, can drive PLK4 symmetry breaking on a either a continuous or compartmentalised Plk4-binding surface, with PLK4 overexpression producing multiple PLK4 foci and PLK4 kinase inhibition leading to a lack of symmetry-breaking and PLK4 accumulation—as observed experimentally. |
| first_indexed | 2024-03-07T08:11:32Z |
| format | Journal article |
| id | oxford-uuid:ba7563ab-5dd9-462b-aa4c-a7ed7fd8407c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:11:32Z |
| publishDate | 2023 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:ba7563ab-5dd9-462b-aa4c-a7ed7fd8407c2023-11-30T17:09:52ZA simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assemblyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ba7563ab-5dd9-462b-aa4c-a7ed7fd8407cEnglishSymplectic ElementsPublic Library of Science2023Wilmott, ZGoriely, ARaff, JCentrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at a single focus that defines the daughter centriole assembly site. How PLK4 breaks symmetry is unclear. Here, we propose that phosphorylated and unphosphorylated species of PLK4 form the 2 components of a classical Turing reaction–diffusion system. These 2 components bind to/unbind from the surface of the mother centriole at different rates, allowing a slow-diffusing activator species of PLK4 to accumulate at a single site on the mother, while a fast-diffusing inhibitor species of PLK4 suppresses activator accumulation around the rest of the centriole. This “short-range activation/long-range inhibition,” inherent to Turing systems, can drive PLK4 symmetry breaking on a either a continuous or compartmentalised Plk4-binding surface, with PLK4 overexpression producing multiple PLK4 foci and PLK4 kinase inhibition leading to a lack of symmetry-breaking and PLK4 accumulation—as observed experimentally. |
| spellingShingle | Wilmott, Z Goriely, A Raff, J A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly |
| title | A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly |
| title_full | A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly |
| title_fullStr | A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly |
| title_full_unstemmed | A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly |
| title_short | A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly |
| title_sort | simple turing reaction diffusion model explains how plk4 breaks symmetry during centriole duplication and assembly |
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