Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy.

Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy.

Familial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant genetic disorder that is characterized by hyperuricemia, gout, and tubulointerstitial nephritis. FJHN is caused by mutations in the UMOD gene, which encodes for uromodulin, the most abundant urinary protein. Herein is demons...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Jennings, P, Aydin, S, Kotanko, P, Lechner, J, Lhotta, K, Williams, S, Thakker, R, Pfaller, W
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2007

Παρόμοια τεκμήρια

UROMODULIN mutations cause familial juvenile hyperuricemic nephropathy.
ανά: Turner, J, κ.ά.
Έκδοση: (2003)

Genetic mapping studies of familial juvenile hyperuricemic nephropathy on chromosome 16p11-p13.
ανά: Stacey, J, κ.ά.
Έκδοση: (2003)

Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.
ανά: Williams, SE, κ.ά.
Έκδοση: (2009)

Epidemiology of uromodulin-associated kidney disease - results from a nation-wide survey.
ανά: Lhotta, K, κ.ά.
Έκδοση: (2012)

Chronic kidney disease in an adolescent with hyperuricemia: familial juvenile hyperuricemic nephropathy
ανά: Demet Alaygut, κ.ά.
Έκδοση: (2013-12-01)

A <it>novel </it>heterozygous <it>missense </it>mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy
ανά: Clemente Carla, κ.ά.
Έκδοση: (2005-01-01)

Uromodulin gene polymorphisms in patients with cast nephropathy in multiple myeloma
ανά: I G Rekhtina, κ.ά.
Έκδοση: (2017-08-01)

Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy
ανά: Chongxiang Xiong, κ.ά.
Έκδοση: (2024-03-01)

Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy
ανά: DAI Zhixin, WANG Yumin
Έκδοση: (2023-02-01)

Establishment and optimization of a novel mouse model of hyperuricemic nephropathy
ανά: Jiamin Wang, κ.ά.
Έκδοση: (2024-12-01)

Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats
ανά: Chongxiang Xiong, κ.ά.
Έκδοση: (2021-02-01)

Validity of Serum Uromodulin as Early Diagnosis Marker of Diabetic Nephropathy in T2DM
ανά: Rizki Dumpatna, κ.ά.
Έκδοση: (2021-06-01)

Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization
ανά: Xue L, κ.ά.
Έκδοση: (2025-01-01)

Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging
ανά: Li He, κ.ά.
Έκδοση: (2022-07-01)

Genome-wide study of familial juvenile hyperuricaemic (gouty) nephropathy (FJHN) indicates a new locus, FJHN3, linked to chromosome 2p22.1-p21.
ανά: Piret, SE, κ.ά.
Έκδοση: (2011)

Genome-wide study of familial juvenile hyperuricaemic (gouty) nephropathy (FJHN) indicates a new locus, FJHN3, linked to chromosome 2p22.1-p21
ανά: Piret, SE, κ.ά.
Έκδοση: (2011)

Familial juvenile hyperuricemic nephropathy: Revisiting the SLC8A1 gene, in a family with a novel terminal gross deletion in the UMOD gene
ανά: Francisco Gonçalves, κ.ά.
Έκδοση: (2024-07-01)

Advances in Research on Pathological and Molecular Mechanism of Hyperuricemic Nephropathy Based on Animal Models
ανά: BAO Fangqi, κ.ά.
Έκδοση: (2024-04-01)

Correlation between serum Klotho and uromodulin expression levels and IgA nephropathy complicated with hyperuricemia
ανά: Di Wei, κ.ά.
Έκδοση: (2024-09-01)

Quercetin ameliorates hyperuricemic nephropathy by repressing uric acid synthesis and reabsorption in mice and cells
ανά: Wenhui Li, κ.ά.
Έκδοση: (2024-04-01)

Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response.
ανά: Céline Schaeffer, κ.ά.
Έκδοση: (2017-01-01)

Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress
ανά: Panshuang Qiao, κ.ά.
Έκδοση: (2023-04-01)

Cyclocarya paliurus leaves alleviate hyperuricemic nephropathy via modulation of purine metabolism, antiinflammation, and antifibrosis
ανά: Rui Gui, κ.ά.
Έκδοση: (2023-04-01)

Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model
ανά: Wang X, κ.ά.
Έκδοση: (2020-06-01)

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
ανά: Martina Brunati, κ.ά.
Έκδοση: (2015-12-01)

Uromodulin and the study of urinary extracellular vesicles
ανά: Michael A. Harding, κ.ά.
Έκδοση: (2024-11-01)

Anti-hyperuricemic effects of three theaflavins isolated from black tea in hyperuricemic mice
ανά: Lingling Tai, κ.ά.
Έκδοση: (2020-03-01)

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice
ανά: Lieqiang Xu, κ.ά.
Έκδοση: (2021-04-01)

Astragaloside IV improves the pharmacokinetics of febuxostat in rats with hyperuricemic nephropathy by regulating urea metabolism in gut microbiota
ανά: Zhen Xiong Zhao, κ.ά.
Έκδοση: (2022-12-01)

Serum Uromodulin, a Potential Biomarker of Tubulointerstitial Damage, Correlates Well with Measured GFR and ERPF in Patients with Obstructive Nephropathy
ανά: Marija Vukmirović Papuga, κ.ά.
Έκδοση: (2022-11-01)

Anti-hyperuricemic Evaluation of Swertia-chirayita and Febuxostat on Potassium Oxonate Induced Hyperuricemic Animal Model
ανά: Qura-Tul-Ain, κ.ά.
Έκδοση: (2024-04-01)

Anti-hyperuricemic Evaluation of Swertia-chirayita and Febuxostat on Potassium Oxonate Induced Hyperuricemic Animal Model
ανά: Qura-Tul-Ain, κ.ά.
Έκδοση: (2024-04-01)

Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids
ανά: Yongmei Li, κ.ά.
Έκδοση: (2022-11-01)

Uromodulin — Biological Significance and Prospects for Clinical Use
ανά: E. S. Levitskaya, κ.ά.
Έκδοση: (2023-01-01)

The role of uromodulin in cardiovascular disease: a review
ανά: Chengqian Chen, κ.ά.
Έκδοση: (2024-07-01)

Serum uromodulin in dogs with chronic kidney disease
ανά: Dansong Seo, κ.ά.
Έκδοση: (2022-11-01)

Localization of the Tamm-Horsfall glycoprotein (uromodulin) gene to chromosome 16p12.3-16p13.11.
ανά: Pook, M, κ.ά.
Έκδοση: (1993)

Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study
ανά: Cornelia Then, κ.ά.
Έκδοση: (2019-10-01)

Possible role of l‐carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic—Fructose‐supplemented rats
ανά: Bataa M. A. El‐Kafoury, κ.ά.
Έκδοση: (2019-11-01)

Available treatment options for hyperuricemic patients
ανά: Mihai-Emil Gherghina, κ.ά.
Έκδοση: (2021-12-01)