Synthesis and bioassay of 4-substituted 2-oxoglutaric acids

Synthesis and bioassay of 4-substituted 2-oxoglutaric acids

Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor-inhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.

Bibliografische gegevens
Hoofdauteurs:	Chen, Q, Liu, Q, Schofield, C
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2006

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