Synthesis and bioassay of 4-substituted 2-oxoglutaric acids

Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor-inhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Chen, Q, Liu, Q, Schofield, C
التنسيق: Journal article
اللغة:English
منشور في: 2006