Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis
Meta-analysis of individual-patient data from eleven double-blind randomized trials found that higher baseline heart rate was associated with greater all-cause mortality for those in sinus rhythm, but not for those in AF. Mortality was lower for patients in sinus rhythm assigned beta-blockers (HR 0....
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2017
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| _version_ | 1797091256550031360 |
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| author | Kotecha, D Flather, M Altman, D Holmes, J Rosano, G Wikstrand, J Packer, M Coats, A Manzano, L Böhm, M van Veldhuisen, D Andersson, B Wedel, H von Lueder, T Rigby, A Hjalmarson, A Kjekshus, J Cleland, J |
| author_facet | Kotecha, D Flather, M Altman, D Holmes, J Rosano, G Wikstrand, J Packer, M Coats, A Manzano, L Böhm, M van Veldhuisen, D Andersson, B Wedel, H von Lueder, T Rigby, A Hjalmarson, A Kjekshus, J Cleland, J |
| author_sort | Kotecha, D |
| collection | OXFORD |
| description | Meta-analysis of individual-patient data from eleven double-blind randomized trials found that higher baseline heart rate was associated with greater all-cause mortality for those in sinus rhythm, but not for those in AF. Mortality was lower for patients in sinus rhythm assigned beta-blockers (HR 0.73, 95% CI 0.67-0.79; p<0.001), regardless of baseline heart rate. Beta-blockers had no effect on mortality in patients with AF (HR 0.96, 95% CI 0.81-1.12; p=0.58) at any heart rate. A lower achieved resting heart rate was associated with better prognosis only for patients in sinus rhythm (HR 1.16 per 10 beats/minute increase, 95% CI 1.11-1.22; p<0.0001). |
| first_indexed | 2024-03-07T03:30:25Z |
| format | Journal article |
| id | oxford-uuid:ba859fb0-59f0-4e94-924a-3b6dac5d0718 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:30:25Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ba859fb0-59f0-4e94-924a-3b6dac5d07182022-03-27T05:10:34ZHeart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ba859fb0-59f0-4e94-924a-3b6dac5d0718Symplectic Elements at OxfordElsevier2017Kotecha, DFlather, MAltman, DHolmes, JRosano, GWikstrand, JPacker, MCoats, AManzano, LBöhm, Mvan Veldhuisen, DAndersson, BWedel, Hvon Lueder, TRigby, AHjalmarson, AKjekshus, JCleland, JMeta-analysis of individual-patient data from eleven double-blind randomized trials found that higher baseline heart rate was associated with greater all-cause mortality for those in sinus rhythm, but not for those in AF. Mortality was lower for patients in sinus rhythm assigned beta-blockers (HR 0.73, 95% CI 0.67-0.79; p<0.001), regardless of baseline heart rate. Beta-blockers had no effect on mortality in patients with AF (HR 0.96, 95% CI 0.81-1.12; p=0.58) at any heart rate. A lower achieved resting heart rate was associated with better prognosis only for patients in sinus rhythm (HR 1.16 per 10 beats/minute increase, 95% CI 1.11-1.22; p<0.0001). |
| spellingShingle | Kotecha, D Flather, M Altman, D Holmes, J Rosano, G Wikstrand, J Packer, M Coats, A Manzano, L Böhm, M van Veldhuisen, D Andersson, B Wedel, H von Lueder, T Rigby, A Hjalmarson, A Kjekshus, J Cleland, J Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis |
| title | Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis |
| title_full | Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis |
| title_fullStr | Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis |
| title_full_unstemmed | Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis |
| title_short | Heart rate, heart rhythm and prognostic benefits of beta-blockers in heart failure: individual patient-data meta-analysis |
| title_sort | heart rate heart rhythm and prognostic benefits of beta blockers in heart failure individual patient data meta analysis |
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