Evaluation of the non-toxic mutant of the diphtheria toxin K51E/E148K as carrier protein for meningococcal vaccines

Diphtheria toxin mutant CRM197 is a common carrier protein for glycoconjugate vaccines, which has been proven an effective protein vector for, among others, meningococcal carbohydrates. The wide-range use of this protein in massive vaccine production requires constant increase of production yields a...

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Hlavní autoři: Pecetta, S, Vijayakrishnan, B, Romano, M, Proietti, D, Surdo, P, Balocchi, C, Mori, E, Davis, B, Berti, F
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2016