Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models

Background: Previous studies have suggested that patients with HER2-low breast cancers do not benefit from trastuzumab treatment although the reasons remain unclear. Methods: We investigated the effect of trastuzumab monotherapy and its combination with different HER2 targeting treatments in a panel...

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Hlavní autoři: Arshad, M, Azad, A, Chan, PYK, Vigneswara, V, Feldinger, K, Nafi, SNM, Laporte-Maguire, E, De Santo, C, Zuo, J, Shaaban, AM, Kong, A
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature [academic journals on nature.com] 2024