Deadenylation is a widespread effect of miRNA regulation.
miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. In animal cells, degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, followed by decapping and subsequent exonucleolytic digestion. To determi...
Үндсэн зохиолчид: | Eulalio, A, Huntzinger, E, Nishihara, T, Rehwinkel, J, Fauser, M, Izaurralde, E |
---|---|
Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2009
|
Ижил төстэй зүйлс
-
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
-н: Eulalio, A, зэрэг
Хэвлэсэн: (2007) -
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.
-н: Rehwinkel, J, зэрэг
Хэвлэсэн: (2005) -
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.
-н: Behm-Ansmant, I, зэрэг
Хэвлэсэн: (2006) -
Rapid nuclear deadenylation of mammalian messenger RNA
-н: Jonathan Alles, зэрэг
Хэвлэсэн: (2023-01-01) -
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
-н: Lorenzo Pavanello, зэрэг
Хэвлэсэн: (2023-04-01)