Deadenylation is a widespread effect of miRNA regulation.

Deadenylation is a widespread effect of miRNA regulation.

miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. In animal cells, degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, followed by decapping and subsequent exonucleolytic digestion. To determi...

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Detalhes bibliográficos
Main Authors:	Eulalio, A, Huntzinger, E, Nishihara, T, Rehwinkel, J, Fauser, M, Izaurralde, E
Formato:	Journal article
Idioma:	English
Publicado em:	2009

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