Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes

Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes

عرض إصدارات أخرى (1)

Genome-wide association studies (GWAS) have been successful in identifying common variants related to complex disorders. However, some disorders have proved resistant to this strategy with few associations confirmed, despite evidence from twin and family studies of a genetic component. Sophisticated...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Traylor, M, Bevan, S, Rothwell, P, Sudlow, C, Dichgans, M, Markus, H, Lewis, C
التنسيق:	Journal article
اللغة:	English
منشور في:	2013

مواد مشابهة

Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes.
حسب: Traylor, M, وآخرون
منشور في: (2013)

The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke
حسب: Thomas, J, وآخرون
منشور في: (2013)

Familiar frequency of ischaemic stroke and transient ischaemic attack in relation to clinical subtype and intermediate phenotypes
حسب: Rothwell, P, وآخرون
منشور في: (2001)

Genome‐wide meta‐analysis identifies 3 novel loci associated with stroke
حسب: Malik, R, وآخرون
منشور في: (2018)

Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations.
حسب: Bevan, S, وآخرون
منشور في: (2012)

Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
حسب: Bevan, S, وآخرون
منشور في: (2012)

Genetic associations with white matter hyperintensities confer risk of lacunar stroke
حسب: Traylor, M, وآخرون
منشور في: (2016)

Confounding of heritability of ischaemic stroke by hypertension and other intermediate phenotypes
حسب: Flossmann, E, وآخرون
منشور في: (2005)

Confounding of heritability of ischaemic stroke by hypertension and other intermediate phenotypes
حسب: Flossmann, E, وآخرون
منشور في: (2004)

Understanding endometriosis heterogeneity—subphenotype analysis of genetic associations
حسب: Cheuk, S, وآخرون
منشور في: (2018)

ARDS Subphenotypes: Understanding a Heterogeneous Syndrome
حسب: Jennifer G. Wilson, وآخرون
منشور في: (2020-03-01)

Potential confounding by intermediate phenotypes in studies of the genetics of ischaemic stroke.
حسب: Flossmann, E, وآخرون
منشور في: (2005)

Atherothrombosis and ischaemic stroke.
حسب: Rothwell, P
منشور في: (2007)

Atherothrombosis and ischaemic stroke
حسب: Rothwell, P
منشور في: (2007)

Immediate aspirin for suspected ischaemic stroke.
حسب: Baigent, C, وآخرون
منشور في: (1999)

History of stroke in first degree relatives of patients with TIA and ischaemic stroke in relation to clinical subtype and intermediate phenotypes
حسب: Schulz, U, وآخرون
منشور في: (2002)

Posterior circulation ischaemic stroke and transient ischaemic attack: diagnosis, investigation, and secondary prevention.
حسب: Markus, H, وآخرون
منشور في: (2013)

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
حسب: Traylor, M, وآخرون
منشور في: (2012)

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies
حسب: Traylor, M, وآخرون
منشور في: (2012)

Recent advances in management of transient ischaemic attacks and minor ischaemic strokes.
حسب: Rothwell, P, وآخرون
منشور في: (2006)

Genetic epidemiology of ischaemic stroke
حسب: Flossmann, E, وآخرون
منشور في: (2004)

Apolipoproteins predict ischaemic stroke in patients with a previous transient ischaemic attack
حسب: Bhatia, M, وآخرون
منشور في: (2004)

Genetics of Common Polygenic Ischaemic Stroke: Current Understanding and Future Challenges
حسب: Steve Bevan, وآخرون
منشور في: (2011-01-01)

Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression
حسب: Emily M. L. Bowman, وآخرون
منشور في: (2021-09-01)

Consistencies and differences in intermediate physiological phenotypes of vascular ageing between ischaemic stroke aetiologies
حسب: Webb, AJS, وآخرون
منشور في: (2022)

Apolipoproteins as predictors of ischaemic stroke in patients with a previous transient ischaemic attack.
حسب: Bhatia, M, وآخرون
منشور في: (2006)

Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression
حسب: Bowman, EML, وآخرون
منشور في: (2021)

Haemoglobian concentration and risk of stroke in 13,000 patients with transient ischaemic attack or minor ischaemic stroke
حسب: Power, D, وآخرون
منشور في: (2004)

Fibrinogen concentration and risk of ischaemic stroke and acute coronary events in 5113 patients with TIA or minor ischaemic stroke
حسب: Rothwell, P, وآخرون
منشور في: (2004)

The need for emergency treatment of TIA and "minor" ischaemic stroke
حسب: Rothwell, P
منشور في: (2005)

Atrial fibrillation genetic risk and ischemic stroke mechanisms
حسب: Lubitz, SA, وآخرون
منشور في: (2017)

Prognosis of vertebrobasilar transient ischaemic attack and minor stroke.
حسب: Flossmann, E, وآخرون
منشور في: (2003)

Unravelling the genetics of ischaemic stroke.
حسب: Hugh S Markus
منشور في: (2010-03-01)

Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke.
حسب: Rothwell, P, وآخرون
منشور في: (2011)

Medical treatment in acute and long-term secondary prevention after transient ischaemic attach and ischaemic stroke
حسب: Rothwell, P, وآخرون
منشور في: (2011)

Refining prediction of major bleeding on antiplatelet treatment after transient ischaemic attack or ischaemic stroke
حسب: Hilkens, NA, وآخرون
منشور في: (2020)

Score to predict early stroke after transient ischaemic attack - Reply
حسب: Rothwell, P
منشور في: (2005)

Carotid artery disease and the risk of ischaemic stroke and coronary vascular events.
حسب: Rothwell, P
منشور في: (2000)

Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study.
حسب: Chinnery, P, وآخرون
منشور في: (2010)

Asymptomatic recurrent cerebral ischaemic lesions on diffusion-weighted imaging in the subacute and chronic phase after transient ischaemic attack or minor ischaemic stroke.
حسب: Mazzucco, S, وآخرون
منشور في: (2007)