Covalent fragment screening and optimization identifies the chloroacetohydrazide scaffold as inhibitors for ubiquitin C-terminal hydrolase L1

Covalent fragment screening and optimization identifies the chloroacetohydrazide scaffold as inhibitors for ubiquitin C-terminal hydrolase L1

Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed primarily in the central nervous system under normal physiological conditions,...

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Bibliografische gegevens
Hoofdauteurs: Imhoff, RD, Patel, R, Safdar, MH, Jones, HBL, Pinto-Fernandez, A, Vendrell, I, Chen, H, Muli, CS, Krabill, AD, Kessler, BM, Wendt, MK, Das, C, Flaherty, DP
Formaat: Journal article
Taal:English
Gepubliceerd in: American Chemical Society 2024

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