Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition.
The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797091438865940480 |
|---|---|
| author | Aleksandrova, K Jenab, M Boeing, H Jansen, E Bueno-de-Mesquita, H Rinaldi, S Riboli, E Overvad, K Dahm, C Olsen, A Tjønneland, A Boutron-Ruault, M Clavel-Chapelon, F Morois, S Palli, D Krogh, V Tumino, R Vineis, P Panico, S Kaaks, R Rohrmann, S Trichopoulou, A Lagiou, P Trichopoulos, D van Duijnhoven, F |
| author_facet | Aleksandrova, K Jenab, M Boeing, H Jansen, E Bueno-de-Mesquita, H Rinaldi, S Riboli, E Overvad, K Dahm, C Olsen, A Tjønneland, A Boutron-Ruault, M Clavel-Chapelon, F Morois, S Palli, D Krogh, V Tumino, R Vineis, P Panico, S Kaaks, R Rohrmann, S Trichopoulou, A Lagiou, P Trichopoulos, D van Duijnhoven, F |
| author_sort | Aleksandrova, K |
| collection | OXFORD |
| description | The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia. |
| first_indexed | 2024-03-07T03:33:05Z |
| format | Journal article |
| id | oxford-uuid:bb5e1058-24c1-4689-8d8f-51bcd30f2329 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:33:05Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:bb5e1058-24c1-4689-8d8f-51bcd30f23292022-03-27T05:16:28ZCirculating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bb5e1058-24c1-4689-8d8f-51bcd30f2329EnglishSymplectic Elements at Oxford2010Aleksandrova, KJenab, MBoeing, HJansen, EBueno-de-Mesquita, HRinaldi, SRiboli, EOvervad, KDahm, COlsen, ATjønneland, ABoutron-Ruault, MClavel-Chapelon, FMorois, SPalli, DKrogh, VTumino, RVineis, PPanico, SKaaks, RRohrmann, STrichopoulou, ALagiou, PTrichopoulos, Dvan Duijnhoven, FThe authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia. |
| spellingShingle | Aleksandrova, K Jenab, M Boeing, H Jansen, E Bueno-de-Mesquita, H Rinaldi, S Riboli, E Overvad, K Dahm, C Olsen, A Tjønneland, A Boutron-Ruault, M Clavel-Chapelon, F Morois, S Palli, D Krogh, V Tumino, R Vineis, P Panico, S Kaaks, R Rohrmann, S Trichopoulou, A Lagiou, P Trichopoulos, D van Duijnhoven, F Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. |
| title | Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. |
| title_full | Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. |
| title_fullStr | Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. |
| title_full_unstemmed | Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. |
| title_short | Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. |
| title_sort | circulating c reactive protein concentrations and risks of colon and rectal cancer a nested case control study within the european prospective investigation into cancer and nutrition |
| work_keys_str_mv | AT aleksandrovak circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT jenabm circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT boeingh circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT jansene circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT buenodemesquitah circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT rinaldis circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT ribolie circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT overvadk circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT dahmc circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT olsena circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT tjønnelanda circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT boutronruaultm circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT clavelchapelonf circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT moroiss circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT pallid circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT kroghv circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT tuminor circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT vineisp circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT panicos circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT kaaksr circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT rohrmanns circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT trichopouloua circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT lagioup circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT trichopoulosd circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition AT vanduijnhovenf circulatingcreactiveproteinconcentrationsandrisksofcolonandrectalcanceranestedcasecontrolstudywithintheeuropeanprospectiveinvestigationintocancerandnutrition |