Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.

Rho-associated kinase 2 (ROCK2) regulates the secretion of proinflammatory cytokines and the development of autoimmunity in mice. Data from a phase 1 clinical trial demonstrate that oral administration of KD025, a selective ROCK2 inhibitor, to healthy human subjects down-regulates the ability of T c...

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Những tác giả chính: Zanin-Zhorov, A, Weiss, J, Nyuydzefe, MS, Chen, W, Scher, J, Mo, R, Depoil, D, Rao, N, Liu, B, Wei, J, Lucas, S, Koslow, M, Roche, M, Schueller, O, Weiss, S, Poyurovsky, M, Tonra, J, Hippen, K, Dustin, M, Blazar, B, Liu, C, Waksal, S
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: National Academy of Sciences 2014

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