Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

The MHC class I allele HLA-B27 is very strongly associated with development of autoimmune spondyloarthritis, although the disease mechanism remains unknown. Class I molecules classically associate in the endoplasmic reticulum (ER) with beta2-microglobulin (beta(2)m) and antigenic peptides for cell s...

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Bibliografiske detaljer
Main Authors:	Bird, L, Peh, C, Kollnberger, S, Elliott, T, Mcmichael, A, Bowness, P
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

Identification and characterisation of cell surface HLA-B27 homodimers
af: Bird, L, et al.
Udgivet: (2002)

Cell-surface expression and immune receptor recognition of HLA-B27 homodimers.
af: Kollnberger, S, et al.
Udgivet: (2002)

HLA-B27 transgenic rodents express cell surface HLA-B27 heavy chain homodimers and multimers.
af: Bowness, P, et al.
Udgivet: (2003)

The pathogenesis of spondyloarthritides - HLA-B-27 homodimer expression on human monocyte/macrophage cell lines
af: McHugh, K, et al.
Udgivet: (2008)

HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.
af: Kollnberger, S, et al.
Udgivet: (2004)

HLA-B-27 heavy chain homodimer formation and natural killer cell family interaction - comparison of two HLA-B-27 subtypes in vitro
af: Giles, J, et al.
Udgivet: (2008)

TARGETING MONOCYTE-EXPRESSED HLA-B27 HOMODIMERS IN ANKYLOSING SPONDYLITIS
af: Bowness, P, et al.
Udgivet: (2010)

TARGETING MONOCYTE-EXPRESSED HLA-B27 HOMODIMERS IN ANKYLOSING SPONDYLITIS
af: Bowness, P, et al.
Udgivet: (2010)

Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.
af: Payeli, S, et al.
Udgivet: (2012)

Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis.
af: Bowness, P, et al.
Udgivet: (2011)

The role of cell surface HLA-B27 heavy chain homodimer interactions with NK receptors in the pathogenesis of spondyloarthritis
af: Kollnberger, S
Udgivet: (2005)

Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide.
af: Kollnberger, S, et al.
Udgivet: (2007)

HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats.
af: Osiris Marroquin Belaunzaran, et al.
Udgivet: (2015-01-01)

HLA B27 can form heavy chain homodimers in vivo and in vivo, possible role of cys 67.
af: Bowness, P, et al.
Udgivet: (1998)

Functional characterisation of HLA-B27 in autoimmunity
af: Kollnberger, S, et al.
Udgivet: (2001)

HLA-B27 homodimers differ in their interactions with LILRB1, LILRB2, KIR3DL1 and KIR3DL2 compared to HLA-B27 heterotrimers
af: Giles, J, et al.
Udgivet: (2010)

HLA-B27 FORMS HEAVY CHAIN HOMODIMERS IN VITRO AND IN VIVO THAT BIND TO CELLULAR RECEPTORS INCLUDING LILR AND KIR FAMILY MEMBERS
af: McHugh, K, et al.
Udgivet: (2010)

Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure.
af: Allen, R, et al.
Udgivet: (1999)

HLA-B*2709, A SUBTYPE NOT ASSOCIATED WITH ANKYLOSING SPONDYLITIS, FORMS FEWER HOMODIMERS THAN HLA-B*2705
af: Giles, J, et al.
Udgivet: (2010)

CELL SURFACE EXPRESSION OF HLA B27 HEAVY CHAINS AND SPECIFIC RECOGNITION BY IMMUNE RECEPTORS, POSSIBLE ROLE IN SPONDYLOARTHROPATHY
af: Kollnberger, S, et al.
Udgivet: (2002)

EXPRESSION OF HLA-B27 HEAVY CHAIN FORMS IN ANKYLOSING SPONDYLITIS AND HLA-B27 POSITIVE CELL LINES
af: Rysnik, O, et al.
Udgivet: (2012)

Direct visualisation of HLA-B27 forms in cell lines and Spondyloarthropathy tissues
af: Rysnik, O, et al.
Udgivet: (2013)

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.
af: Giles, J, et al.
Udgivet: (2012)

Dimers are forever. Expression and recognition of abnormal HLA-B27 in spondylo arthritis
af: Bowness, P, et al.
Udgivet: (2005)

Residue Cys-67 of HLA-B27 contributes to antigen presentation and T cell recognition of HLA-B27 restricted T cell epitopes.
af: Appel, H, et al.
Udgivet: (2004)

The KIRs of HLA-B27: the role of HLA-B27 KIR interactions in infection and spondyloarthritis
af: Wong-Baeza, I, et al.
Udgivet: (2011)

The role of HLA-B27 in spondyloarthritis.
af: Allen, R, et al.
Udgivet: (1999)

IDENTIFICATION OF T-CELL RECEPTOR RECOGNITION RESIDUES FOR AN INFLUENZA-VIRUS NONAMER PEPTIDE EPITOPE PRESENTED BY HLA B27
af: Bowness, P, et al.
Udgivet: (1995)

The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes.
af: Appel, H, et al.
Udgivet: (2004)

Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27.
af: Bowness, P, et al.
Udgivet: (1994)

HLA-B27: natural function and pathogenic role in spondyloarthritis.
af: McMichael, A, et al.
Udgivet: (2002)

HLA-B27
af: Bowness, P
Udgivet: (2015)

Factors determining the cell surface expression of a novel HLA-B27 epitope
af: McHugh, K, et al.
Udgivet: (2010)

HLA-B27-RESTRICTED PEPTIDE PRESENTATION TO CYTOTOXIC T-CELLS IN REACTIVE ARTHRITIS
af: Bowness, P, et al.
Udgivet: (1995)

The role of HLA-B27 interactions with natural killer receptors in the pathogenesis of spondyloarthritis
af: Kollnberger, S, et al.
Udgivet: (2007)

KIR3DL2 INTERACTION WITH HLA-B27 PROMOTES THE SURVIVAL OF TH17 CELLS IN ANKYLOSING SPONDYLITIS
af: Kollnberger, S, et al.
Udgivet: (2010)

Molecular Characterisation Of The Killer Cell Immunoglobulin-Like Receptor 3DL2 Binding To Aberrant HLA-B27 Heavy Chains In Spondyloarthritis
af: Hatano, H, et al.
Udgivet: (2013)

THE ARTHRITIS-ASSOCIATED HLA-B(star)27:05 FORMS MORE CELL SURFACE B27 DIMER AND FREE HEAVY CHAIN LIGANDS FOR KIR3DL2 AND LILRB2 IMMUNORECEPTORS THAN HLA(star)B27:09
af: Shaw, J, et al.
Udgivet: (2013)

HLA-B27 and KIR3DL2 Interactions Promote The Differentiation and Survival Of Proinflammatory T Cells In Spondyloarthritis
af: Ridley, A, et al.
Udgivet: (2013)

Molecular determinants for KIR3DL2 binding to HLA-B27 and other HLA-class I ligands
af: Hatano, H, et al.
Udgivet: (2013)