Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) poses a constant threat to human health. The viral spike protein (SARS-S) mediates host cell entry and is a potential target for antiviral intervention. Activation of SARS-S by host cell proteases is essential for SARS-Co...

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Main Authors: Bertram, S, Glowacka, I, Müller, M, Lavender, H, Gnirss, K, Nehlmeier, I, Niemeyer, D, He, Y, Simmons, G, Drosten, C, Soilleux, E, Jahn, O, Steffen, I, Pöhlmann, S
Format: Journal article
Language:English
Published: American Society for Microbiology 2011

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