Image-assisted surgical planning in gynaecological oncology
<p>Major barriers to achieving progress in gynaecological cancer management are limitations in ovarian cancer treatment and morbidity related to lymphadenectomy in early stage cervical, vulval and endometrial cancers. The main morbidity of treatments for early endometrial, cervical and vulval...
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| Other Authors: | |
| Format: | Thesis |
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2017
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| _version_ | 1797091505397039104 |
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| author | Pathiraja, P |
| author2 | Ahmed, A |
| author_facet | Ahmed, A Pathiraja, P |
| author_sort | Pathiraja, P |
| collection | OXFORD |
| description | <p>Major barriers to achieving progress in gynaecological cancer management are limitations in ovarian cancer treatment and morbidity related to lymphadenectomy in early stage cervical, vulval and endometrial cancers. The main morbidity of treatments for early endometrial, cervical and vulval cancers is surgery. Currently, all patients with high-‐grade endometrial cancers, cervical cancers and squamous cell cancers of the vulva receive a complete regional lymphadenectomy. Complete lymphadenectomy causes significant morbidity, affecting the long-‐term quality of life for these patients. There has been an emphasis on sentinel node biopsy to eliminate these morbidities, and some cancer centres already provide sentinel lymph node biopsy using radioactive isotopes, without compromising patient survival. Our study mainly focuses on a novel imaging technique using near infrared (NIR) with compatible dyes. We demonstrated the feasibility and efficacy of using intraoperative NIR for sentinel lymph node biopsy. </p> <p>Advanced ovarian cancer management involves a combination of surgery and chemotherapy. The aim of surgery is to remove all visible disease before commencing chemotherapy or mid-‐way during chemotherapy. Limitations to radical surgery are the unpredictability of radicality from available imaging modalities and patient morbidity. Limitations to chemotherapy are the limited response or resistance, mainly due to tumour heterogeneity. Our ovarian cancer pilot study aims to explore methods that could overcome the limitations of surgical planning prior to radical surgery and to identify tumour resistance in specific tumour sites by tracking the tumours during chemotherapy.</p> |
| first_indexed | 2024-03-07T03:34:05Z |
| format | Thesis |
| id | oxford-uuid:bbb4816c-dfd4-4d60-abf9-3280647db62e |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:34:05Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | oxford-uuid:bbb4816c-dfd4-4d60-abf9-3280647db62e2022-03-27T05:18:52ZImage-assisted surgical planning in gynaecological oncologyThesishttp://purl.org/coar/resource_type/c_bdccuuid:bbb4816c-dfd4-4d60-abf9-3280647db62eORA Deposit2017Pathiraja, PAhmed, A<p>Major barriers to achieving progress in gynaecological cancer management are limitations in ovarian cancer treatment and morbidity related to lymphadenectomy in early stage cervical, vulval and endometrial cancers. The main morbidity of treatments for early endometrial, cervical and vulval cancers is surgery. Currently, all patients with high-‐grade endometrial cancers, cervical cancers and squamous cell cancers of the vulva receive a complete regional lymphadenectomy. Complete lymphadenectomy causes significant morbidity, affecting the long-‐term quality of life for these patients. There has been an emphasis on sentinel node biopsy to eliminate these morbidities, and some cancer centres already provide sentinel lymph node biopsy using radioactive isotopes, without compromising patient survival. Our study mainly focuses on a novel imaging technique using near infrared (NIR) with compatible dyes. We demonstrated the feasibility and efficacy of using intraoperative NIR for sentinel lymph node biopsy. </p> <p>Advanced ovarian cancer management involves a combination of surgery and chemotherapy. The aim of surgery is to remove all visible disease before commencing chemotherapy or mid-‐way during chemotherapy. Limitations to radical surgery are the unpredictability of radicality from available imaging modalities and patient morbidity. Limitations to chemotherapy are the limited response or resistance, mainly due to tumour heterogeneity. Our ovarian cancer pilot study aims to explore methods that could overcome the limitations of surgical planning prior to radical surgery and to identify tumour resistance in specific tumour sites by tracking the tumours during chemotherapy.</p> |
| spellingShingle | Pathiraja, P Image-assisted surgical planning in gynaecological oncology |
| title | Image-assisted surgical planning in gynaecological oncology |
| title_full | Image-assisted surgical planning in gynaecological oncology |
| title_fullStr | Image-assisted surgical planning in gynaecological oncology |
| title_full_unstemmed | Image-assisted surgical planning in gynaecological oncology |
| title_short | Image-assisted surgical planning in gynaecological oncology |
| title_sort | image assisted surgical planning in gynaecological oncology |
| work_keys_str_mv | AT pathirajap imageassistedsurgicalplanningingynaecologicaloncology |