Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues

The load-bearing biomechanical role of the intervertebral disc is governed by the composition and organization of its major macromolecular components, collagen and aggrecan. The major function of aggrecan is to maintain tissue hydration, and hence disc height, under the high loads imposed by muscle...

Full description

Bibliographic Details
Main Authors: Sivan, S, Roberts, S, Urban, J, Menage, J, Bramhill, J, Campbell, D, Franklin, V, Lydon, F, Merkher, Y, Maroudas, A, Tighe, B
Format: Journal article
Language:English
Published: 2014