Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being equally suppressed. This inhibition correlated with the selective impairment of exocytosis evoked by brief (action potential-like) depo...

書誌詳細
主要な著者:	Hoppa, M, Collins, S, Ramracheya, R, Hodson, L, Amisten, S, Zhang, Q, Johnson, P, Ashcroft, F, Rorsman, P
フォーマット:	Journal article
言語:	English
出版事項:	2009

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