Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being equally suppressed. This inhibition correlated with the selective impairment of exocytosis evoked by brief (action potential-like) depo...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Hoppa, M, Collins, S, Ramracheya, R, Hodson, L, Amisten, S, Zhang, Q, Johnson, P, Ashcroft, F, Rorsman, P
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2009

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-н: Braun, M, зэрэг
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-н: Eliasson, L, зэрэг
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-н: Bokvist, K, зэрэг
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-н: Renstrom, E, зэрэг
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-н: Soni, A, зэрэг
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-н: Ramracheya, R, зэрэг
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-н: Rorsman, P, зэрэг
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Ca(2+)-induced Ca2+ release in insulin-secreting cells.
-н: Islam, MS, зэрэг
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-н: Ashcroft, F, зэрэг
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-н: Braun, M, зэрэг
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-н: Macdonald, P, зэрэг
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-н: Olofsson, C, зэрэг
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-н: Eliasson, L, зэрэг
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-н: Ashcroft, F, зэрэг
Хэвлэсэн: (1990)

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-н: Braun, M, зэрэг
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-н: Eliasson, L, зэрэг
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-н: Rorsman, P, зэрэг
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Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.
-н: Eliasson, L, зэрэг
Хэвлэсэн: (1996)

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-н: Renström, E, зэрэг
Хэвлэсэн: (2008)

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-н: Obermüller, S, зэрэг
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-н: Rorsman, P, зэрэг
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-н: Barg, S, зэрэг
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-н: Zhang, Q, зэрэг
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-н: Clark, A, зэрэг
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-н: Zhang, Q, зэрэг
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-н: Rorsman, P, зэрэг
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-н: Olofsson, C, зэрэг
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-н: Barg, S, зэрэг
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