Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics
A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal–organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest–host interactions arising from nano...
| Main Authors: | , , , , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
Royal Society of Chemistry
2019
|
| _version_ | 1826293739876777984 |
|---|---|
| author | Souza, BE Rudic, S Titov, K Babal, AS Taylor, JD Tan, J-C |
| author_facet | Souza, BE Rudic, S Titov, K Babal, AS Taylor, JD Tan, J-C |
| author_sort | Souza, BE |
| collection | OXFORD |
| description | A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal–organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest–host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation. |
| first_indexed | 2024-03-07T03:34:49Z |
| format | Journal article |
| id | oxford-uuid:bbec2594-feed-4fa8-9ec2-e580cc9e5b4d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:34:49Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:bbec2594-feed-4fa8-9ec2-e580cc9e5b4d2022-03-27T05:20:34ZGuest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamicsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bbec2594-feed-4fa8-9ec2-e580cc9e5b4dEnglishSymplectic Elements at OxfordRoyal Society of Chemistry2019Souza, BERudic, STitov, KBabal, ASTaylor, JDTan, J-CA facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal–organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest–host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation. |
| spellingShingle | Souza, BE Rudic, S Titov, K Babal, AS Taylor, JD Tan, J-C Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics |
| title | Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics |
| title_full | Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics |
| title_fullStr | Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics |
| title_full_unstemmed | Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics |
| title_short | Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics |
| title_sort | guest host interactions of nanoconfined anti cancer drug in metal organic framework exposed by terahertz dynamics |
| work_keys_str_mv | AT souzabe guesthostinteractionsofnanoconfinedanticancerdruginmetalorganicframeworkexposedbyterahertzdynamics AT rudics guesthostinteractionsofnanoconfinedanticancerdruginmetalorganicframeworkexposedbyterahertzdynamics AT titovk guesthostinteractionsofnanoconfinedanticancerdruginmetalorganicframeworkexposedbyterahertzdynamics AT babalas guesthostinteractionsofnanoconfinedanticancerdruginmetalorganicframeworkexposedbyterahertzdynamics AT taylorjd guesthostinteractionsofnanoconfinedanticancerdruginmetalorganicframeworkexposedbyterahertzdynamics AT tanjc guesthostinteractionsofnanoconfinedanticancerdruginmetalorganicframeworkexposedbyterahertzdynamics |