Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.
The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibi...
Main Authors: | , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
1999
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author | Sewell, A Gerth, U Price, D Purbhoo, M Boulter, J Gao, G Bell, J Phillips, R Jakobsen, B |
author_facet | Sewell, A Gerth, U Price, D Purbhoo, M Boulter, J Gao, G Bell, J Phillips, R Jakobsen, B |
author_sort | Sewell, A |
collection | OXFORD |
description | The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-cell surface. These results provide new insights into the mechanism of T-cell activation and evidence that CD8 function is exquisitely sensitive to disruption, an effect that might be exploited by molecular therapeutics. |
first_indexed | 2024-03-07T03:34:49Z |
format | Journal article |
id | oxford-uuid:bbed70f3-c01d-4cd1-b7e9-98776b8edd3a |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T03:34:49Z |
publishDate | 1999 |
record_format | dspace |
spelling | oxford-uuid:bbed70f3-c01d-4cd1-b7e9-98776b8edd3a2022-03-27T05:20:34ZAntagonism of cytotoxic T-lymphocyte activation by soluble CD8.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bbed70f3-c01d-4cd1-b7e9-98776b8edd3aEnglishSymplectic Elements at Oxford1999Sewell, AGerth, UPrice, DPurbhoo, MBoulter, JGao, GBell, JPhillips, RJakobsen, BThe CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-cell surface. These results provide new insights into the mechanism of T-cell activation and evidence that CD8 function is exquisitely sensitive to disruption, an effect that might be exploited by molecular therapeutics. |
spellingShingle | Sewell, A Gerth, U Price, D Purbhoo, M Boulter, J Gao, G Bell, J Phillips, R Jakobsen, B Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. |
title | Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. |
title_full | Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. |
title_fullStr | Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. |
title_full_unstemmed | Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. |
title_short | Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. |
title_sort | antagonism of cytotoxic t lymphocyte activation by soluble cd8 |
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