GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.

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RATIONALE: Cardiac myosin-binding protein C (cMyBP-C) regulates cross-bridge cycling kinetics and, thereby, fine-tunes the rate of cardiac muscle contraction and relaxation. Its effects on cardiac kinetics are modified by phosphorylation. Three phosphorylation sites (Ser275, Ser284, and Ser304) have...

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Detalles Bibliográficos
Autores principales: Kuster, D, Sequeira, V, Najafi, A, Boontje, N, Wijnker, P, Witjas-Paalberends, E, Marston, S, Dos Remedios, C, Carrier, L, Demmers, J, Redwood, C, Sadayappan, S, van der Velden, J
Formato: Journal article
Lenguaje:English
Publicado: 2013

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