Tetraspanin in oncogenic epithelial-mesenchymal transition.
Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpressio...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826293755054915584 |
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| author | Muschel, R Gal, A |
| author_facet | Muschel, R Gal, A |
| author_sort | Muschel, R |
| collection | OXFORD |
| description | Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpression of the tetraspanin superfamily member TM4SF5 in human hepatocellular carcinoma cells causes cellular phenotypic changes that resemble classical descriptions of epithelial-mesenchymal transition (EMT), with some unique aspects (see the related article beginning on page 1354). They also show that these TM4SF5-mediated effects trigger tumor formation when these cells are injected into mice. The study implicates TM4SF5, for the first time to our knowledge, in EMT oncogenic pathways of cancer progression. |
| first_indexed | 2024-03-07T03:35:02Z |
| format | Journal article |
| id | oxford-uuid:bc00148b-c121-441b-8738-9f1ceffd1b20 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:35:02Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:bc00148b-c121-441b-8738-9f1ceffd1b202022-03-27T05:21:12ZTetraspanin in oncogenic epithelial-mesenchymal transition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc00148b-c121-441b-8738-9f1ceffd1b20EnglishSymplectic Elements at Oxford2008Muschel, RGal, AMembers of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpression of the tetraspanin superfamily member TM4SF5 in human hepatocellular carcinoma cells causes cellular phenotypic changes that resemble classical descriptions of epithelial-mesenchymal transition (EMT), with some unique aspects (see the related article beginning on page 1354). They also show that these TM4SF5-mediated effects trigger tumor formation when these cells are injected into mice. The study implicates TM4SF5, for the first time to our knowledge, in EMT oncogenic pathways of cancer progression. |
| spellingShingle | Muschel, R Gal, A Tetraspanin in oncogenic epithelial-mesenchymal transition. |
| title | Tetraspanin in oncogenic epithelial-mesenchymal transition. |
| title_full | Tetraspanin in oncogenic epithelial-mesenchymal transition. |
| title_fullStr | Tetraspanin in oncogenic epithelial-mesenchymal transition. |
| title_full_unstemmed | Tetraspanin in oncogenic epithelial-mesenchymal transition. |
| title_short | Tetraspanin in oncogenic epithelial-mesenchymal transition. |
| title_sort | tetraspanin in oncogenic epithelial mesenchymal transition |
| work_keys_str_mv | AT muschelr tetraspanininoncogenicepithelialmesenchymaltransition AT gala tetraspanininoncogenicepithelialmesenchymaltransition |