The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review
To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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MDPI
2021
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| _version_ | 1797091577562136576 |
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| author | Nduva, GM Nazziwa, J Hassan, AS Sanders, EJ Esbjörnsson, J |
| author_facet | Nduva, GM Nazziwa, J Hassan, AS Sanders, EJ Esbjörnsson, J |
| author_sort | Nduva, GM |
| collection | OXFORD |
| description | To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995–2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges. |
| first_indexed | 2024-03-07T03:35:05Z |
| format | Journal article |
| id | oxford-uuid:bc039e23-c6e0-4ca5-98d3-93d42daa3347 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:35:05Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:bc039e23-c6e0-4ca5-98d3-93d42daa33472022-03-27T05:21:17ZThe role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc039e23-c6e0-4ca5-98d3-93d42daa3347EnglishSymplectic ElementsMDPI2021Nduva, GMNazziwa, JHassan, ASSanders, EJEsbjörnsson, JTo reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995–2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges. |
| spellingShingle | Nduva, GM Nazziwa, J Hassan, AS Sanders, EJ Esbjörnsson, J The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review |
| title | The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review |
| title_full | The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review |
| title_fullStr | The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review |
| title_full_unstemmed | The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review |
| title_short | The role of phylogenetics in discerning HIV-1 mixing among vulnerable populations and geographic regions in Sub-Saharan Africa: A systematic review |
| title_sort | role of phylogenetics in discerning hiv 1 mixing among vulnerable populations and geographic regions in sub saharan africa a systematic review |
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