Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9.

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9.

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Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens. Here, we present the crystal structure of the first assembly intermediate, C5b6, together with a cryo-electron microscopy reconstruct...

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Main Authors: Hadders, M, Bubeck, D, Roversi, P, Hakobyan, S, Forneris, F, Morgan, B, Pangburn, M, Llorca, O, Lea, S, Gros, P
格式: Journal article
語言:English
出版: 2012
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