Genetic susceptibility to ankylosing spondylitis.
Ankylosing spondylitis is a highly heritable, common rheumatic condition, primarily affecting the axial skeleton. The association with HLA-B27 has been demonstrated worldwide, and evidence for a role of HLA-B27 in disease comes from linkage and association studies in humans, and transgenic animal mo...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797091625248227328 |
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| author | Sims, A Wordsworth, B Brown, M |
| author_facet | Sims, A Wordsworth, B Brown, M |
| author_sort | Sims, A |
| collection | OXFORD |
| description | Ankylosing spondylitis is a highly heritable, common rheumatic condition, primarily affecting the axial skeleton. The association with HLA-B27 has been demonstrated worldwide, and evidence for a role of HLA-B27 in disease comes from linkage and association studies in humans, and transgenic animal models. However, twin studies indicate that HLA-B27 contributes only 16% of the total genetic risk for disease. Furthermore, there is compelling evidence that non-B27 genes, both within and outwith the major histocompatability complex, are involved in disease aetiology. In this post-genomic era we have the tools to help elicit the genetic basis of disease. This review describes methods for genetic investigation of ankylosing spondylitis, and summarises the status of current research in this exciting area. |
| first_indexed | 2024-03-07T03:35:43Z |
| format | Journal article |
| id | oxford-uuid:bc37502f-716e-43bf-b5b8-3931df764ed9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:35:43Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:bc37502f-716e-43bf-b5b8-3931df764ed92022-03-27T05:22:43ZGenetic susceptibility to ankylosing spondylitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc37502f-716e-43bf-b5b8-3931df764ed9EnglishSymplectic Elements at Oxford2004Sims, AWordsworth, BBrown, MAnkylosing spondylitis is a highly heritable, common rheumatic condition, primarily affecting the axial skeleton. The association with HLA-B27 has been demonstrated worldwide, and evidence for a role of HLA-B27 in disease comes from linkage and association studies in humans, and transgenic animal models. However, twin studies indicate that HLA-B27 contributes only 16% of the total genetic risk for disease. Furthermore, there is compelling evidence that non-B27 genes, both within and outwith the major histocompatability complex, are involved in disease aetiology. In this post-genomic era we have the tools to help elicit the genetic basis of disease. This review describes methods for genetic investigation of ankylosing spondylitis, and summarises the status of current research in this exciting area. |
| spellingShingle | Sims, A Wordsworth, B Brown, M Genetic susceptibility to ankylosing spondylitis. |
| title | Genetic susceptibility to ankylosing spondylitis. |
| title_full | Genetic susceptibility to ankylosing spondylitis. |
| title_fullStr | Genetic susceptibility to ankylosing spondylitis. |
| title_full_unstemmed | Genetic susceptibility to ankylosing spondylitis. |
| title_short | Genetic susceptibility to ankylosing spondylitis. |
| title_sort | genetic susceptibility to ankylosing spondylitis |
| work_keys_str_mv | AT simsa geneticsusceptibilitytoankylosingspondylitis AT wordsworthb geneticsusceptibilitytoankylosingspondylitis AT brownm geneticsusceptibilitytoankylosingspondylitis |