Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar.
Fifty-two patients who had been bitten by Russell's vipers in Myanmar developed acute renal failure (serum creatinine exceeding 1.3 mg/dL). Thirty-four of them (65%) became oliguric, but the other 18 (35%) maintained a urine output of more than 400 mL/24 h. In oliguric patients, gastrointestina...
| Hlavní autoři: | , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1993
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| _version_ | 1826293799603666944 |
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| author | Tin-Nu-Swe Tin-Tun Myint-Lwin Thein-Than Tun-Pe Robertson, J Leckie, B Phillips, R Warrell, D |
| author_facet | Tin-Nu-Swe Tin-Tun Myint-Lwin Thein-Than Tun-Pe Robertson, J Leckie, B Phillips, R Warrell, D |
| author_sort | Tin-Nu-Swe |
| collection | OXFORD |
| description | Fifty-two patients who had been bitten by Russell's vipers in Myanmar developed acute renal failure (serum creatinine exceeding 1.3 mg/dL). Thirty-four of them (65%) became oliguric, but the other 18 (35%) maintained a urine output of more than 400 mL/24 h. In oliguric patients, gastrointestinal haemorrhages, renal angle tenderness and conjunctival oedema occurred more commonly, and peak serum creatinine, blood urea nitrogen and the fractional excretion of sodium were significantly higher (P < 0.01) than in non-oliguric patients, indicating a greater degree of renal damage. Urinary concentrations of beta 2 microglobulin and retinol binding protein were raised in most of the patients indicating failure of proximal tubular reabsorption of these proteins, while high urinary N-acetyl glucosaminidase concentrations were consistent with renal tubular damage. Plasma concentrations of active renin were very high, suggesting that renal ischaemia, associated with activation of the renin-angiotensin system, was involved in the development of renal dysfunction. |
| first_indexed | 2024-03-07T03:35:44Z |
| format | Journal article |
| id | oxford-uuid:bc37f3e5-02b5-4dae-ad4c-cdef21f24255 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:35:44Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:bc37f3e5-02b5-4dae-ad4c-cdef21f242552022-03-27T05:22:49ZRenal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc37f3e5-02b5-4dae-ad4c-cdef21f24255EnglishSymplectic Elements at Oxford1993Tin-Nu-SweTin-TunMyint-LwinThein-ThanTun-PeRobertson, JLeckie, BPhillips, RWarrell, DFifty-two patients who had been bitten by Russell's vipers in Myanmar developed acute renal failure (serum creatinine exceeding 1.3 mg/dL). Thirty-four of them (65%) became oliguric, but the other 18 (35%) maintained a urine output of more than 400 mL/24 h. In oliguric patients, gastrointestinal haemorrhages, renal angle tenderness and conjunctival oedema occurred more commonly, and peak serum creatinine, blood urea nitrogen and the fractional excretion of sodium were significantly higher (P < 0.01) than in non-oliguric patients, indicating a greater degree of renal damage. Urinary concentrations of beta 2 microglobulin and retinol binding protein were raised in most of the patients indicating failure of proximal tubular reabsorption of these proteins, while high urinary N-acetyl glucosaminidase concentrations were consistent with renal tubular damage. Plasma concentrations of active renin were very high, suggesting that renal ischaemia, associated with activation of the renin-angiotensin system, was involved in the development of renal dysfunction. |
| spellingShingle | Tin-Nu-Swe Tin-Tun Myint-Lwin Thein-Than Tun-Pe Robertson, J Leckie, B Phillips, R Warrell, D Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar. |
| title | Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar. |
| title_full | Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar. |
| title_fullStr | Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar. |
| title_full_unstemmed | Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar. |
| title_short | Renal ischaemia, transient glomerular leak and acute renal tubular damage in patients envenomed by Russell's vipers (Daboia russelii siamensis) in Myanmar. |
| title_sort | renal ischaemia transient glomerular leak and acute renal tubular damage in patients envenomed by russell s vipers daboia russelii siamensis in myanmar |
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