A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies.
The impact of erroneous genotypes having passed standard quality control (QC) can be severe in genome-wide association studies, genotype imputation, and estimation of heritability and prediction of genetic risk based on single nucleotide polymorphisms (SNP). To detect such genotyping errors, a simpl...
Автори: | Lee, S, Nyholt, DR, Macgregor, S, Henders, A, Zondervan, K, Montgomery, G, Visscher, P |
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Формат: | Journal article |
Мова: | English |
Опубліковано: |
2010
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