Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
SAGE Publications
2021
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| _version_ | 1797113170571034624 |
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| author | Wang, W Balfe, P Eyre, DW Lumley, SF O'Donnell, D Warren, F Crook, DW Jeffery, K Matthews, PC Klerman, EB McKeating, JA |
| author_facet | Wang, W Balfe, P Eyre, DW Lumley, SF O'Donnell, D Warren, F Crook, DW Jeffery, K Matthews, PC Klerman, EB McKeating, JA |
| author_sort | Wang, W |
| collection | OXFORD |
| description | The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy. |
| first_indexed | 2024-04-09T03:59:09Z |
| format | Journal article |
| id | oxford-uuid:bc579135-77e5-4955-9644-582f7e4bf776 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:59:09Z |
| publishDate | 2021 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:bc579135-77e5-4955-9644-582f7e4bf7762024-04-08T07:21:15ZTime of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workersJournal articlehttp://purl.org/coar/resource_type/c_545buuid:bc579135-77e5-4955-9644-582f7e4bf776EnglishSymplectic ElementsSAGE Publications2021Wang, WBalfe, PEyre, DWLumley, SFO'Donnell, DWarren, FCrook, DWJeffery, KMatthews, PCKlerman, EBMcKeating, JAThe COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy. |
| spellingShingle | Wang, W Balfe, P Eyre, DW Lumley, SF O'Donnell, D Warren, F Crook, DW Jeffery, K Matthews, PC Klerman, EB McKeating, JA Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers |
| title | Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers |
| title_full | Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers |
| title_fullStr | Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers |
| title_full_unstemmed | Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers |
| title_short | Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers |
| title_sort | time of day of vaccination affects sars cov 2 antibody responses in an observational study of health care workers |
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