Modelling systemic risk factors in cardiovascular disease using single-cell biology
The plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2023
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| _version_ | 1797112291111469056 |
|---|---|
| author | Monaco, C Dib, L |
| author_facet | Monaco, C Dib, L |
| author_sort | Monaco, C |
| collection | OXFORD |
| description | The plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesis of cardiovascular disease. |
| first_indexed | 2024-03-07T08:22:06Z |
| format | Journal article |
| id | oxford-uuid:bc6e3e91-e164-4f68-b8e8-61ebf9ad1601 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:22:06Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:bc6e3e91-e164-4f68-b8e8-61ebf9ad16012024-01-31T15:20:48ZModelling systemic risk factors in cardiovascular disease using single-cell biologyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc6e3e91-e164-4f68-b8e8-61ebf9ad1601EnglishSymplectic ElementsSpringer Nature2023Monaco, CDib, LThe plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesis of cardiovascular disease. |
| spellingShingle | Monaco, C Dib, L Modelling systemic risk factors in cardiovascular disease using single-cell biology |
| title | Modelling systemic risk factors in cardiovascular disease using single-cell biology |
| title_full | Modelling systemic risk factors in cardiovascular disease using single-cell biology |
| title_fullStr | Modelling systemic risk factors in cardiovascular disease using single-cell biology |
| title_full_unstemmed | Modelling systemic risk factors in cardiovascular disease using single-cell biology |
| title_short | Modelling systemic risk factors in cardiovascular disease using single-cell biology |
| title_sort | modelling systemic risk factors in cardiovascular disease using single cell biology |
| work_keys_str_mv | AT monacoc modellingsystemicriskfactorsincardiovasculardiseaseusingsinglecellbiology AT dibl modellingsystemicriskfactorsincardiovasculardiseaseusingsinglecellbiology |