Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents.
Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localization (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles...
| Auteurs principaux: | , , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
Institute of Physics
2017
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| _version_ | 1826293842687557632 |
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| author | Peng, Y Lui, C Chen, Y Chou, S Chou, P Yung, K Tsang, S |
| author_facet | Peng, Y Lui, C Chen, Y Chou, S Chou, P Yung, K Tsang, S |
| author_sort | Peng, Y |
| collection | OXFORD |
| description | Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localization (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent (DMCA) for neural stem cells imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent neural stem cells from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible. |
| first_indexed | 2024-03-07T03:36:24Z |
| format | Journal article |
| id | oxford-uuid:bc6fffe4-2f2d-4d96-99cb-4d4a8decf42f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:36:24Z |
| publishDate | 2017 |
| publisher | Institute of Physics |
| record_format | dspace |
| spelling | oxford-uuid:bc6fffe4-2f2d-4d96-99cb-4d4a8decf42f2022-03-27T05:24:22ZEngineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc6fffe4-2f2d-4d96-99cb-4d4a8decf42fEnglishSymplectic Elements at OxfordInstitute of Physics2017Peng, YLui, CChen, YChou, SChou, PYung, KTsang, STagging recognition group(s) on superparamagnetic iron oxide is known to aid localization (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent (DMCA) for neural stem cells imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent neural stem cells from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible. |
| spellingShingle | Peng, Y Lui, C Chen, Y Chou, S Chou, P Yung, K Tsang, S Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. |
| title | Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. |
| title_full | Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. |
| title_fullStr | Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. |
| title_full_unstemmed | Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. |
| title_short | Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. |
| title_sort | engineered core shell magnetic nanoparticle for mr dual modal tracking and safe magnetic manipulation of ependymal cells in live rodents |
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