E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer

E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer

The MRE11/RAD50/NBS1 (MRN) complex mediates DNA repair pathways, including double-strand breaks induced by radiotherapy. Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in reduced levels of DNA repair in bladder cancer cells and radiosen...

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Detalles Bibliográficos
Autores principales:	Nicholson, J, Jevons, S, Groselj, B, Ellermann, S, Konietzny, R, Kerr, M, Kessler, B, Kiltie, A
Formato:	Journal article
Publicado:	American Association for Cancer Research 2017

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