Modelling Oscillator synchronisation during vertebrate axis segmentation
he somitogenesis clock regulates the periodicity with which somites form in the posterior pre-somitic mesoderm. Whilst cell heterogeneity results in noisy oscillation rates amongst constituent cells, synchrony within the population is maintained as oscillators are entrained via juxtracine signalling...
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| Materiálatiipa: | Book section |
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Springer-Verlag Berlin Heidelberg
2013
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| _version_ | 1826293863330873344 |
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| author | Murray, P Maini, P Baker, R |
| author_facet | Murray, P Maini, P Baker, R |
| author_sort | Murray, P |
| collection | OXFORD |
| description | he somitogenesis clock regulates the periodicity with which somites form in the posterior pre-somitic mesoderm. Whilst cell heterogeneity results in noisy oscillation rates amongst constituent cells, synchrony within the population is maintained as oscillators are entrained via juxtracine signalling mechanisms. Here we consider a population of phase-coupled oscillators and investigate how biologically motivated perturbations to the entrained state can perturb synchrony within the population. We find that the ratio of mitosis length to clock period can influence levels of desynchronisation. Moreover, we observe that random cell movement, and hence change of local neighbourhoods, increases synchronisation. |
| first_indexed | 2024-03-07T03:36:43Z |
| format | Book section |
| id | oxford-uuid:bc8b45b2-6842-405f-bee6-7da6dad9271a |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:36:43Z |
| publishDate | 2013 |
| publisher | Springer-Verlag Berlin Heidelberg |
| record_format | dspace |
| spelling | oxford-uuid:bc8b45b2-6842-405f-bee6-7da6dad9271a2022-03-27T05:25:04ZModelling Oscillator synchronisation during vertebrate axis segmentationBook sectionhttp://purl.org/coar/resource_type/c_3248uuid:bc8b45b2-6842-405f-bee6-7da6dad9271aMathematical Institute - ePrintsSpringer-Verlag Berlin Heidelberg2013Murray, PMaini, PBaker, Rhe somitogenesis clock regulates the periodicity with which somites form in the posterior pre-somitic mesoderm. Whilst cell heterogeneity results in noisy oscillation rates amongst constituent cells, synchrony within the population is maintained as oscillators are entrained via juxtracine signalling mechanisms. Here we consider a population of phase-coupled oscillators and investigate how biologically motivated perturbations to the entrained state can perturb synchrony within the population. We find that the ratio of mitosis length to clock period can influence levels of desynchronisation. Moreover, we observe that random cell movement, and hence change of local neighbourhoods, increases synchronisation. |
| spellingShingle | Murray, P Maini, P Baker, R Modelling Oscillator synchronisation during vertebrate axis segmentation |
| title | Modelling Oscillator synchronisation during vertebrate axis segmentation |
| title_full | Modelling Oscillator synchronisation during vertebrate axis segmentation |
| title_fullStr | Modelling Oscillator synchronisation during vertebrate axis segmentation |
| title_full_unstemmed | Modelling Oscillator synchronisation during vertebrate axis segmentation |
| title_short | Modelling Oscillator synchronisation during vertebrate axis segmentation |
| title_sort | modelling oscillator synchronisation during vertebrate axis segmentation |
| work_keys_str_mv | AT murrayp modellingoscillatorsynchronisationduringvertebrateaxissegmentation AT mainip modellingoscillatorsynchronisationduringvertebrateaxissegmentation AT bakerr modellingoscillatorsynchronisationduringvertebrateaxissegmentation |