Regulatory T cells.
Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen. A transcription factor, Foxp3, has b...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797091698219679744 |
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| author | Thompson, C Powrie, F |
| author_facet | Thompson, C Powrie, F |
| author_sort | Thompson, C |
| collection | OXFORD |
| description | Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen. A transcription factor, Foxp3, has been identified that is essential for CD4(+)CD25+ TR cell development and function. There is now evidence that transforming growth factor-beta might play a role in this pathway. CD4(+)CD25+ TR cells proliferate extensively in vivo in an antigen-specific manner, and can respond to both self and foreign peptides. By suppressing excessive immune responses, TR cells play a key role in the maintenance of self-tolerance, thus preventing autoimmune disease, as well as inhibiting harmful inflammatory diseases such as asthma and inflammatory bowel disease. |
| first_indexed | 2024-03-07T03:36:43Z |
| format | Journal article |
| id | oxford-uuid:bc8b8bf8-0b65-4d15-8fe5-7595ec21979d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:36:43Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:bc8b8bf8-0b65-4d15-8fe5-7595ec21979d2022-03-27T05:25:08ZRegulatory T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc8b8bf8-0b65-4d15-8fe5-7595ec21979dEnglishSymplectic Elements at Oxford2004Thompson, CPowrie, FRegulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen. A transcription factor, Foxp3, has been identified that is essential for CD4(+)CD25+ TR cell development and function. There is now evidence that transforming growth factor-beta might play a role in this pathway. CD4(+)CD25+ TR cells proliferate extensively in vivo in an antigen-specific manner, and can respond to both self and foreign peptides. By suppressing excessive immune responses, TR cells play a key role in the maintenance of self-tolerance, thus preventing autoimmune disease, as well as inhibiting harmful inflammatory diseases such as asthma and inflammatory bowel disease. |
| spellingShingle | Thompson, C Powrie, F Regulatory T cells. |
| title | Regulatory T cells. |
| title_full | Regulatory T cells. |
| title_fullStr | Regulatory T cells. |
| title_full_unstemmed | Regulatory T cells. |
| title_short | Regulatory T cells. |
| title_sort | regulatory t cells |
| work_keys_str_mv | AT thompsonc regulatorytcells AT powrief regulatorytcells |