Chemical and hydrodynamic alignment of an enzyme
Motivated by the implications of the complex and dynamic modular geometry of an enzyme on its motion, we investigate the effect of combining long-range internal and external hydrodynamic interactions due to thermal fluctuations with short-range surface interactions. An asymmetric dumbbell consisting...
| Huvudupphovsmän: | , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
AIP Publishing
2019
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| _version_ | 1826293865079898112 |
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| author | Adeleke-Larodo, T Agudo-Canalejo, J Golestanian, R |
| author_facet | Adeleke-Larodo, T Agudo-Canalejo, J Golestanian, R |
| author_sort | Adeleke-Larodo, T |
| collection | OXFORD |
| description | Motivated by the implications of the complex and dynamic modular geometry of an enzyme on its motion, we investigate the effect of combining long-range internal and external hydrodynamic interactions due to thermal fluctuations with short-range surface interactions. An asymmetric dumbbell consisting of two unequal subunits, in a nonuniform suspension of a solute with which it interacts via hydrodynamic interactions as well as non-contact surface interactions, is shown to have two alignment mechanisms due to the two types of interactions. In addition to alignment, the chemical gradient results in a drift velocity that is modified by hydrodynamic interactions between the constituents of the enzyme. |
| first_indexed | 2024-03-07T03:36:45Z |
| format | Journal article |
| id | oxford-uuid:bc8da60a-d7ed-4fc7-8bf6-9d3fe04a3cb3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:36:45Z |
| publishDate | 2019 |
| publisher | AIP Publishing |
| record_format | dspace |
| spelling | oxford-uuid:bc8da60a-d7ed-4fc7-8bf6-9d3fe04a3cb32022-03-27T05:25:11ZChemical and hydrodynamic alignment of an enzymeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc8da60a-d7ed-4fc7-8bf6-9d3fe04a3cb3EnglishSymplectic Elements at OxfordAIP Publishing2019Adeleke-Larodo, TAgudo-Canalejo, JGolestanian, RMotivated by the implications of the complex and dynamic modular geometry of an enzyme on its motion, we investigate the effect of combining long-range internal and external hydrodynamic interactions due to thermal fluctuations with short-range surface interactions. An asymmetric dumbbell consisting of two unequal subunits, in a nonuniform suspension of a solute with which it interacts via hydrodynamic interactions as well as non-contact surface interactions, is shown to have two alignment mechanisms due to the two types of interactions. In addition to alignment, the chemical gradient results in a drift velocity that is modified by hydrodynamic interactions between the constituents of the enzyme. |
| spellingShingle | Adeleke-Larodo, T Agudo-Canalejo, J Golestanian, R Chemical and hydrodynamic alignment of an enzyme |
| title | Chemical and hydrodynamic alignment of an enzyme |
| title_full | Chemical and hydrodynamic alignment of an enzyme |
| title_fullStr | Chemical and hydrodynamic alignment of an enzyme |
| title_full_unstemmed | Chemical and hydrodynamic alignment of an enzyme |
| title_short | Chemical and hydrodynamic alignment of an enzyme |
| title_sort | chemical and hydrodynamic alignment of an enzyme |
| work_keys_str_mv | AT adelekelarodot chemicalandhydrodynamicalignmentofanenzyme AT agudocanalejoj chemicalandhydrodynamicalignmentofanenzyme AT golestanianr chemicalandhydrodynamicalignmentofanenzyme |