Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom.
The therapeutic effects of antithrombin III (AT-III) and unrefined equine antivenom in the treatment of coagulopathy induced by Malayan pit viper (Calloselasma rhodostoma) venom were assessed in 42 adult Wistar rats. Following intramuscular venom injection (2 micrograms/g body weight), serial blood...
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
1994
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| _version_ | 1826293865675489280 |
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| author | Pukrittayakamee, S Clemens, R Nontprasert, A Desakorn, V Charoenlarp, P Chongsuphajaisiddhi, T White, N |
| author_facet | Pukrittayakamee, S Clemens, R Nontprasert, A Desakorn, V Charoenlarp, P Chongsuphajaisiddhi, T White, N |
| author_sort | Pukrittayakamee, S |
| collection | OXFORD |
| description | The therapeutic effects of antithrombin III (AT-III) and unrefined equine antivenom in the treatment of coagulopathy induced by Malayan pit viper (Calloselasma rhodostoma) venom were assessed in 42 adult Wistar rats. Following intramuscular venom injection (2 micrograms/g body weight), serial blood samples were taken from the femoral vein for measurement of whole blood clotting time and AT-III activity. There was progressive depletion of AT-III and blood ceased to clot a mean (S.E.) of 164 (8.3) min after venom injection. Coagulopathy was reversed by a high dose antivenom (10 micrograms/g) or a lower dose of antivenom (5 micrograms/g) in combination with AT-III (> or = 0.1 U/g; P < 0.01) but not 5 micrograms/g antivenom or AT-III alone. Following successful treatment, the mean plasma AT-III activity remained above 90%. In this animal model, systemic envenomation by the Malayan pit viper causes uncoagulable blood associated with AT-III consumption. The dose of antivenom required to reverse this coagulopathy can be reduced by half by the addition of AT-III sufficient to maintain blood concentrations within the normal range. |
| first_indexed | 2024-03-07T03:36:45Z |
| format | Journal article |
| id | oxford-uuid:bc8e4bd8-c79a-44ac-8947-47e8fa243e3d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:36:45Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:bc8e4bd8-c79a-44ac-8947-47e8fa243e3d2022-03-27T05:25:10ZAntithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc8e4bd8-c79a-44ac-8947-47e8fa243e3dEnglishSymplectic Elements at Oxford1994Pukrittayakamee, SClemens, RNontprasert, ADesakorn, VCharoenlarp, PChongsuphajaisiddhi, TWhite, NThe therapeutic effects of antithrombin III (AT-III) and unrefined equine antivenom in the treatment of coagulopathy induced by Malayan pit viper (Calloselasma rhodostoma) venom were assessed in 42 adult Wistar rats. Following intramuscular venom injection (2 micrograms/g body weight), serial blood samples were taken from the femoral vein for measurement of whole blood clotting time and AT-III activity. There was progressive depletion of AT-III and blood ceased to clot a mean (S.E.) of 164 (8.3) min after venom injection. Coagulopathy was reversed by a high dose antivenom (10 micrograms/g) or a lower dose of antivenom (5 micrograms/g) in combination with AT-III (> or = 0.1 U/g; P < 0.01) but not 5 micrograms/g antivenom or AT-III alone. Following successful treatment, the mean plasma AT-III activity remained above 90%. In this animal model, systemic envenomation by the Malayan pit viper causes uncoagulable blood associated with AT-III consumption. The dose of antivenom required to reverse this coagulopathy can be reduced by half by the addition of AT-III sufficient to maintain blood concentrations within the normal range. |
| spellingShingle | Pukrittayakamee, S Clemens, R Nontprasert, A Desakorn, V Charoenlarp, P Chongsuphajaisiddhi, T White, N Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom. |
| title | Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom. |
| title_full | Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom. |
| title_fullStr | Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom. |
| title_full_unstemmed | Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom. |
| title_short | Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom. |
| title_sort | antithrombin iii and antivenom reversal of coagulopathy in rats envenomated with malayan pit viper venom |
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