The tumour hypoxia induced non-coding transcriptome.
Recent investigations have highlighted the importance of the non-coding genome in regions of hypoxia in tumours. Such regions are frequently found in solid tumours, and are associated with worse patient survival and therapy resistance. Hypoxia stabilises the transcription factors, hypoxia inducible...
| المؤلفون الرئيسيون: | , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Elsevier
2016
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| _version_ | 1826293876279738368 |
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| author | Choudhry, H Harris, A McIntyre, A |
| author_facet | Choudhry, H Harris, A McIntyre, A |
| author_sort | Choudhry, H |
| collection | OXFORD |
| description | Recent investigations have highlighted the importance of the non-coding genome in regions of hypoxia in tumours. Such regions are frequently found in solid tumours, and are associated with worse patient survival and therapy resistance. Hypoxia stabilises the transcription factors, hypoxia inducible factors (HIF1α and HIF2α) which coordinate transcriptomic changes that occur in hypoxia. The changes in gene expression induced by HIF1α and HIF2α contribute to many of the hallmarks of cancer phenotypes and enable tumour growth, survival and invasion in the hypoxic tumour microenvironment. Non-coding RNAs, in particular microRNAs (miRNAs), which regulate mRNA stability and translation, and long-non-coding RNAs (lncRNAs), which have diverse functions including chromatin modification and transcriptional regulation, are also important in enabling the key hypoxia regulated processes. They have roles in the regulation of metabolism, angiogenesis, autophagy, invasion and metastasis in the hypoxic microenvironment. Furthermore, HIF1α and HIF2α expression and stabilisation are also regulated by both miRNAs and lncRNAs. Here we review the recent developments in the expression, regulation and functions of miRNAs, lncRNAs and other non-coding RNA classes in tumour hypoxia. |
| first_indexed | 2024-03-07T03:36:55Z |
| format | Journal article |
| id | oxford-uuid:bc9c96a8-4cab-4bb5-8cd3-3a2c067980d8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:36:55Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:bc9c96a8-4cab-4bb5-8cd3-3a2c067980d82022-03-27T05:25:37ZThe tumour hypoxia induced non-coding transcriptome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc9c96a8-4cab-4bb5-8cd3-3a2c067980d8EnglishSymplectic Elements at OxfordElsevier2016Choudhry, HHarris, AMcIntyre, ARecent investigations have highlighted the importance of the non-coding genome in regions of hypoxia in tumours. Such regions are frequently found in solid tumours, and are associated with worse patient survival and therapy resistance. Hypoxia stabilises the transcription factors, hypoxia inducible factors (HIF1α and HIF2α) which coordinate transcriptomic changes that occur in hypoxia. The changes in gene expression induced by HIF1α and HIF2α contribute to many of the hallmarks of cancer phenotypes and enable tumour growth, survival and invasion in the hypoxic tumour microenvironment. Non-coding RNAs, in particular microRNAs (miRNAs), which regulate mRNA stability and translation, and long-non-coding RNAs (lncRNAs), which have diverse functions including chromatin modification and transcriptional regulation, are also important in enabling the key hypoxia regulated processes. They have roles in the regulation of metabolism, angiogenesis, autophagy, invasion and metastasis in the hypoxic microenvironment. Furthermore, HIF1α and HIF2α expression and stabilisation are also regulated by both miRNAs and lncRNAs. Here we review the recent developments in the expression, regulation and functions of miRNAs, lncRNAs and other non-coding RNA classes in tumour hypoxia. |
| spellingShingle | Choudhry, H Harris, A McIntyre, A The tumour hypoxia induced non-coding transcriptome. |
| title | The tumour hypoxia induced non-coding transcriptome. |
| title_full | The tumour hypoxia induced non-coding transcriptome. |
| title_fullStr | The tumour hypoxia induced non-coding transcriptome. |
| title_full_unstemmed | The tumour hypoxia induced non-coding transcriptome. |
| title_short | The tumour hypoxia induced non-coding transcriptome. |
| title_sort | tumour hypoxia induced non coding transcriptome |
| work_keys_str_mv | AT choudhryh thetumourhypoxiainducednoncodingtranscriptome AT harrisa thetumourhypoxiainducednoncodingtranscriptome AT mcintyrea thetumourhypoxiainducednoncodingtranscriptome AT choudhryh tumourhypoxiainducednoncodingtranscriptome AT harrisa tumourhypoxiainducednoncodingtranscriptome AT mcintyrea tumourhypoxiainducednoncodingtranscriptome |