Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

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Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phen...

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Hauptverfasser:	Alivernini, S, MacDonald, L, Elmesmari, A, Finlay, S, Tolusso, B, Gigante, MR, Petricca, L, Di Mario, C, Bui, L, Perniola, S, Attar, M, Gessi, M, Fedele, AL, Chilaka, S, Somma, D, Sansom, SN, Filer, A, McSharry, C, Millar, NL, Kirschner, K, Nerviani, A, Lewis, MJ, Pitzalis, C, Clark, AR, Ferraccioli, G, Udalova, I, Buckley, CD, Gremese, E, McInnes, IB, Otto, TD, Kurowska-Stolarska, M
Format:	Journal article
Sprache:	English
Veröffentlicht:	Nature Research 2020

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