Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

The asparaginyl hydroxylase, factor-inhibiting hypoxia-inducible factor (HIF), is central to the oxygen-sensing pathway that controls the activity of HIF. Factor-inhibiting HIF (FIH) also catalyzes the hydroxylation of a large set of proteins that share a structural motif termed the ankyrin repeat d...

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Hlavní autoři: Singleton, R, Trudgian, D, Fischer, R, Kessler, B, Ratcliffe, P, Cockman, M
Médium: Journal article
Jazyk:English
Vydáno: 2011

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