Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release.
The prolactin responses to the serotonin (5-HT) releasing agent d-fenfluramine (30 mg orally) were studied in 11 male normal volunteers after administration of hydrocortisone (20 mg orally, twice daily for 10 days) using a double-blind, placebo-controlled, cross-over design. While hydrocortisone tre...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1797091769859440640 |
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| author | Young, A Rue, J Odontiadis, J Cowen, P |
| author_facet | Young, A Rue, J Odontiadis, J Cowen, P |
| author_sort | Young, A |
| collection | OXFORD |
| description | The prolactin responses to the serotonin (5-HT) releasing agent d-fenfluramine (30 mg orally) were studied in 11 male normal volunteers after administration of hydrocortisone (20 mg orally, twice daily for 10 days) using a double-blind, placebo-controlled, cross-over design. While hydrocortisone treatment significantly elevated 24-h urinary cortisol excretion, it did not lower the prolactin response to d-fenfluramine. Plasma levels of d-fenfluramine and d-norfenfluramine were not altered by hydrocortisone treatment. These findings show that following 10 days administration of hydrocortisone, the prolactin responses to d-fenfluramine are not changed. |
| first_indexed | 2024-03-07T03:37:15Z |
| format | Journal article |
| id | oxford-uuid:bcb5b352-c566-45eb-a128-0fa5ade4f175 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:37:15Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:bcb5b352-c566-45eb-a128-0fa5ade4f1752022-03-27T05:26:21ZLack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bcb5b352-c566-45eb-a128-0fa5ade4f175EnglishSymplectic Elements at Oxford1998Young, ARue, JOdontiadis, JCowen, PThe prolactin responses to the serotonin (5-HT) releasing agent d-fenfluramine (30 mg orally) were studied in 11 male normal volunteers after administration of hydrocortisone (20 mg orally, twice daily for 10 days) using a double-blind, placebo-controlled, cross-over design. While hydrocortisone treatment significantly elevated 24-h urinary cortisol excretion, it did not lower the prolactin response to d-fenfluramine. Plasma levels of d-fenfluramine and d-norfenfluramine were not altered by hydrocortisone treatment. These findings show that following 10 days administration of hydrocortisone, the prolactin responses to d-fenfluramine are not changed. |
| spellingShingle | Young, A Rue, J Odontiadis, J Cowen, P Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. |
| title | Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. |
| title_full | Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. |
| title_fullStr | Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. |
| title_full_unstemmed | Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. |
| title_short | Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. |
| title_sort | lack of effect of hydrocortisone treatment on d fenfluramine mediated prolactin release |
| work_keys_str_mv | AT younga lackofeffectofhydrocortisonetreatmentondfenfluraminemediatedprolactinrelease AT ruej lackofeffectofhydrocortisonetreatmentondfenfluraminemediatedprolactinrelease AT odontiadisj lackofeffectofhydrocortisonetreatmentondfenfluraminemediatedprolactinrelease AT cowenp lackofeffectofhydrocortisonetreatmentondfenfluraminemediatedprolactinrelease |