Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be c...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797091785550331904 |
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| author | Goodman, R Schaap, I Tardin, C Erben, C Berry, R Schmidt, C Turberfield, A |
| author_facet | Goodman, R Schaap, I Tardin, C Erben, C Berry, R Schmidt, C Turberfield, A |
| author_sort | Goodman, R |
| collection | OXFORD |
| description | Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads. |
| first_indexed | 2024-03-07T03:37:29Z |
| format | Journal article |
| id | oxford-uuid:bcc73583-8de6-4337-9a1b-e5452edb25ff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:37:29Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:bcc73583-8de6-4337-9a1b-e5452edb25ff2022-03-27T05:26:52ZRapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bcc73583-8de6-4337-9a1b-e5452edb25ffEnglishSymplectic Elements at Oxford2005Goodman, RSchaap, ITardin, CErben, CBerry, RSchmidt, CTurberfield, APractical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads. |
| spellingShingle | Goodman, R Schaap, I Tardin, C Erben, C Berry, R Schmidt, C Turberfield, A Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. |
| title | Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. |
| title_full | Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. |
| title_fullStr | Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. |
| title_full_unstemmed | Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. |
| title_short | Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. |
| title_sort | rapid chiral assembly of rigid dna building blocks for molecular nanofabrication |
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