Linker histone H1.2 directs genome-wide chromatin association of the retinoblastoma tumor suppressor protein and facilitates its function
The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We establish that H1.2 and pRb are found in a ch...
| Hauptverfasser: | , , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
2017
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